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Home>Press>脊髓损伤的“epipen”

显示骨骼系统的人体示意图,with the lower spine highlighted in red to indicate pain spots.Image courtesy: Michigan Engineering
显示骨骼系统的人体示意图,with the lower spine highlighted in red to indicate pain spots.Image courtesy: Michigan Engineering

摘要:
An injection of nanoparticles can prevent the body's immune system from overreacting to trauma,可能防止一些脊髓损伤导致瘫痪。

An 'EpiPen' for spinal cord injuries

Ann Arbor,MI | Posted on July 12th,2019年

这种方法在密歇根大学的老鼠身上得到了证实。with the nanoparticles enhancing healing by reprogramming the aggressive immune cells--call it an "EpiPen" for trauma to the central nervous system,which includes the brain and spinal cord.

“在这项工作中,我们证明,与其克服免疫反应,我们可以选择免疫反应来促进治疗反应。the Steven A.Goldstein Collegiate Professor of Biomedical Engineering.

任何形式的创伤都会使身体的免疫反应加速。In a normal injury,immune cells infiltrate the damaged area and clear debris to initiate the regenerative process.

The central nervous system,however,is usually walled off from the rough-and-tumble of immune activity by the blood-brain barrier.A spinal cord injury breaks that barrier,letting in overzealous immune cells that create too much inflammation for the delicate neural tissues.导致神经元迅速死亡,damage to the insulating sheaths around nerve fibers that allow them to send signals,and the formation of a scar that blocks the regeneration of the spinal cord's nerve cells.

所有这些都会导致低于损伤水平的功能丧失。That spectrum includes everything from paralysis to a loss of sensation for many of the 12,000 new spinal injury patients each year in the United States.

以前尝试通过注射甲基强的松龙之类的类固醇来抵消免疫反应带来的并发症。That practice has largely been discarded since it comes with side effects that include sepsis,gastrointestinal bleeding and blood clots.The risks outweigh the benefits.

但是现在,U-M researchers have designed nanoparticles that intercept immune cells on their way to the spinal cord,redirecting them away from the injury.Those that reach the spinal cord have been altered to be more pro-regenerative.

With no drugs attached,the nanoparticles reprogram the immune cells with their physical characteristics: a size similar to cell debris and a negative charge that facilitates binding to immune cells.理论上,their nonpharmaceutical nature avoids unwanted side effects.

With fewer immune cells at the trauma location,there is less inflammation and tissue deterioration.第二个,immune cells that do make it to the injury are less inflammatory and more suited to supporting tissues that are trying to grow back together.

“希望,this technology could lead to new therapeutic strategies not only for patients with spinal cord injury but for those with various inflammatory diseases," said Jonghyuck Park,一个与谢伊合作的U-M研究员。

Previous research has shown success for nanoparticles mitigating trauma caused by the West Nile virus and multiple sclerosis,for example.

“免疫系统是自身免疫疾病的基础,癌症,trauma,再生——几乎所有的主要疾病,”谢伊说。"Tools that can target immune cells and reprogram them to a desired response have numerous opportunities for treating or managing disease."

###

The research,published in the current issue of Proceedings of the National Academy of Sciences,was supported by The National Institutes of Health.谢伊还是威廉和瓦莱丽霍尔生物医学工程主席和化学工程教授。

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Contacts:
Nicole Casal Moore

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